IN VITRO EFFECT OF PSYCHOTROPIC DRUGS ON THE ACTIVITY OF LEUKOCYTE ELASTASEстатья
Статья опубликована в журнале из списка RSCI Web of Science
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
Аннотация:Objective. To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE). Methods. The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people. Results. Aminazine and melipramine inhibited the LE activity. Conclusions. The dose-dependent inhibiting effect of aminazine and melipramine was shown.