T-Cadherin Deficiency Is Associated with Increased Blood Pressure after Physical Activity

Popov, V.S.; Brodsky, I.B.; Balatskaya, M.N.; Balatskiy, A.V.; Ozhimalov, I.D.; Kulebyakina, M.A.; Semina, E.V.; Arbatskiy, M.S.; Isakova, V.S.; Klimovich, P.S.; Sysoeva, V.Y.; Kalinina, N.I.; Tkachuk, V.A.; Rubina, K.A.

Авторы: Popov V.S., Brodsky I.B., Balatskaya M.N., Balatskiy A.V., Ozhimalov I.D., Kulebyakina M.A., Semina E.V., Arbatskiy M.S., Isakova V.S., Klimovich P.S., Sysoeva V.Y., Kalinina N.I., Tkachuk V.A., Rubina K.A.
Журнал: International Journal of Molecular Sciences
Том: 24
Номер: 18
Год издания: 2023
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 14204
DOI: 10.3390/ijms241814204
Аннотация: T-cadherin is a regulator of blood vessel remodeling and angiogenesis, involved in adiponectin-mediated protective effects in the cardiovascular system and in skeletal muscles. GWAS study has previously demonstrated a SNP in the Cdh13 gene to be associated with hypertension. However, the role of T-cadherin in regulating blood pressure has not been experimentally elucidated. Herein, we generated Cdh13∆Exon3 mice lacking exon 3 in the Cdh13 gene and described their phenotype. Cdh13∆Exon3 mice exhibited normal gross morphology, life expectancy, and breeding capacity. Meanwhile, their body weight was considerably lower than of WT mice. When running on a treadmill, the time spent running and the distance covered by Cdh13∆Exon3 mice was similar to that of WT. The resting blood pressure in Cdh13∆Exon3 mice was slightly higher than in WT, however, upon intensive physical training their systolic blood pressure was significantly elevated. While adiponectin content in the myocardium of Cdh13∆Exon3 and WT mice was within the same range, adiponectin plasma level was 4.37-fold higher in Cdh13∆Exon3 mice. Moreover, intensive physical training augmented the AMPK phosphorylation in the skeletal muscles and myocardium of Cdh13∆Exon3 mice as compared to WT. Our data highlight a critically important role of T-cadherin in regulation of blood pressure and stamina in mice, and may shed light on the pathogenesis of hypertension.
Добавил в систему: Кулебякина Мария Александровна

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