Molecular and Cellular Mechanisms Governing Adipogenic Differentiation

Sysoeva, V.Y.; Lazarev, M.A.; Kulebyakin, K.Y.; Semina, E.V.; Rubina, K.A.

Авторы: Sysoeva V.Y., Lazarev M.A., Kulebyakin K.Y., Semina E.V., Rubina K.A.
Журнал: Russian Journal of Developmental Biology
Том: 54
Год издания: 2024
Издательство: Springer Verlag
Местоположение издательства: Germany
Первая страница: S10
Последняя страница: S22
DOI: 10.1134/S1062360423070068
Аннотация: Adipose tissue is a special type of connective tissue that comprises stromal-vascular cells, committed preadipocytes, and mature adipocytes. Adipose tissue exhibits high plasticity and is capable of both rapidphysiological expansion and reduction in response to dietary changes. Under normal conditions, an increasein adipose tissue volume occurs through hyperplasia, while tissue expansion in obesity results from hypertrophy of existing adipocytes. Adipose tissue cells not only store energy in the form of triglycerides but alsosecrete crucial adipokines, regulating the overall body metabolism. In metabolic syndrome and obesity, alterations affect not only adipose tissue morphology but also adipocyte renewal and differentiation as well as thehormonal and secretory functions. The fundamental mechanisms regulating cell renewal and differentiationin adipose tissue warrant detailed investigation to comprehend the metabolic processes in the entire organism, both under normal and pathological conditions. This review provides insights into the principal regulators governing the transcriptional program that controls adipogenesis, as well as the key signaling cascadesthat influence adipocyte differentiation
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